News November 2019, Graduate students Shao-Ting and Chan-Min presented in The 20th International Conference on Systems Biology in Okinawa.
November 2019, Congratulations on Wen-Wei receiving MOST PhD student scholarship!
September 2019, Welcome Ging-Hsiang and Chi-Rong join the lab.
August 2019, Chen Chang and Ko-Hong Lin presented in The 9th WACBE World Congress in Bioengineering in Taipei.
July 2019, JC and Yu-Zhi visited MIB lab in CUHK in summer 2019.
June 2019, Graduate student Chen Chang successfully defends his master's thesis!

Research Our lab focuses on studying the roles of mitochondria in cellular bioenergetics and metabolism using systemic and quantitative methods. We are developing computational models and tools based on quantitative data as the projects listed below

• Building differential equation-based mitochondria model in cardiac myocytes to study the energy supply and demand in the heart

We are developing a multi-compartment computational model to describe mitochondrial bioenergetics and metabolic signaling the cardiac myocytes.


• Studying mitochondrial dynamics in aging

Mitochondria undergo morphological changes in response to cellular signals and environmental stimuli through the processes of fusion and fission together with biogenesis and mitophagy. We are interested in building mitochondrial dynamics computational models to understand the energetics changes in aging and disease states.


• Developing Metabolic Network Model to study metabolic shift in diseases
We are developing a genome-scale metabolic network model based on multi-omics data to study the impacts on mitochondrial dysfunction in the metabolic pathways and network.


• Image analysis of mitochondria morphology and dynamics
We use high-resolution imaging and sophisticated image analysis algorithms to examine mitochondrial morphology and function in the cells. We use a combination of structural and functional markers to delineate the mitochondrial structure and quantify network formation.